How NAD Supplements Help Fight Fatigue
How NAD+ Supplements Help Fight Fatigue
If you find yourself feeling worn out, mentally foggy, or struggling to get through the day, you're not alone. Fatigue is increasingly common with age, despite eating well, remaining active, and getting enough sleep.
One reason for this is because NAD+ (nicotinamide adenine dinucleotide), a coenzyme vital for cellular energy production and mitochondrial function, can drop by more than 50% by the time you reach your 40s.[1]
NAD+ supplementation offers a promising way to restore energy so you can continue doing what you love with youthful vitality. In this article, you’ll discover how NAD+ may be the key to overcoming persistent fatigue.
What Is NAD+ and What Does It Do in the Body?
NAD+ is a coenzyme found in every cell of your body, and it helps power your mitochondria—the part of your cells that generate energy. As you get older, NAD+ levels naturally decline. However, things like chronic stress, poor sleep, environmental toxins, or a demanding lifestyle can deplete NAD+ levels faster.[2]
Without adequate NAD+, your cells can’t produce energy efficiently, and the effects often show up as fatigue.[1]
If life after your 20s has been particularly busy and stressful—as it is for so many of us—low NAD+ levels may be behind your unexplained fatigue. The good news is that emerging research shows NAD+ supplementation can help boost NAD+ levels and combat fatigue naturally.[3]
How Does NAD+ Help With Fatigue?
Fatigue can manifest as low stamina, reduced focus, and a sense that your body and mind are no longer working in sync. As NAD+ levels fall—whether due to age, stress, or environmental toxins—your mitochondria can’t generate energy as efficiently, and you may start noticing those frustrating signs of fatigue. By restoring NAD+ through supplementation, you can help reactivate the mitochondrial function your cells need to generate energy more effectively.[4]
Research also indicates that NAD+ supports the activation of sirtuin enzymes, which help regulate cellular repair and stress response. This means supplementing NAD+ can not only fuel energy production but also improve your body’s resilience to stress, speed up recovery, and maintain youthful vitality.[4]
What Are the Benefits of NAD+ for People With Fatigue?
Life after 30 often comes with complexities and challenges that contribute to fatigue, no matter how well you take care of yourself. For people feeling tired in this stage of life, NAD+ offers three key benefits:
- Improved Metabolic Function.Metabolism tends to slow down with age. Cells don’t convert food into usable energy as efficiently, which can make you feel tired even after getting enough sleep and eating well. Because NAD+ can help your mitochondria break down nutrients for energy, restoring its levels can give your metabolism a boost for more sustained energy levels throughout the day.[45]
- Enhanced Mental Clarity.Low NAD+ levels can impair mitochondrial function in the brain, contributing to mental fatigue.[5] By replenishing NAD+, you can support cognitive health at the root and remain clear-headed—even under pressure.
- Better Physical Recovery. Slow recovery after physical activity (prolonged soreness or fatigue) may be a sign that your muscles aren’t getting enough energy. Research shows that NAD+ is an important player in converting glucose into the energy your muscles need for daily use and proper recovery.[6]
Who Should Consider Taking NAD+ for Fatigue?
A high-quality NAD+ supplement may be right if you…
…are 30+ and starting to notice a difference in your daily energy levels despite maintaining healthy habits.
…feel mentally foggy or forgetful, especially during times of high stress or hormonal fluctuations.
…lead a demanding lifestyle, often feeling depleted at the end of the day and still tired in the mornings.
…don’t recover as quickly from exercise, poor sleep, or stress.
…want to maintain youthful vitality in your thirties and beyond.
Do You Choose the Best NAD+ Supplement?
As with all supplements, you have to look carefully when choosing the best one. Here are some things to consider while shopping:
- Purity: Free from artificial additives, fillers, and contaminants
- Bioavailability: Formulas that your body can absorb and use effectively
- Third-party testing: Independent verification to ensure safety, potency, and ingredient accuracy
Global Healing’s NAD+ supplement combines these qualities with MicroSomal® Technology for the purest, most bioavailable third-party tested NAD+ supplement on the market.
Combat Fatigue Naturally with MicroSomal® NAD+
If you’re feeling mentally foggy, physically drained, or simply not like yourself, the answer may lie at the cellular level. By restoring NAD+ through supplementation, you can support your body’s natural energy systems to feel clear, strong, and fully present again.
Shop MicroSomal® NAD+ to experience the difference it can make for your energy levels.
†Results may vary. Information and statements made are for education purposes and are not intended to replace the advice of your doctor. If you have a severe medical condition or health concern, see your physician.
References (6)
- McReynolds, M. R., Chellappa, K., & Baur, J. A. (2020). Age-related NAD+ decline. Experimental Gerontology, 134, 110888. https://doi.org/10.1016/j.exger.2020.110888
- Poljsak, B., & Milisav, I. (2016). NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair, Longevity, and Health Span. Rejuvenation Research, 19(5), 406–413. https://doi.org/10.1089/rej.2015.1767
- Conlon, N. J. (2021). The Role of NAD+ in Regenerative Medicine. Plastic & Reconstructive Surgery, 150, 41S48S. https://doi.org/10.1097/prs.0000000000009673
- Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology, 24(8), 464–471. https://doi.org/10.1016/j.tcb.2014.04.002
- Zhao, Y., Zhang, J., Zheng, Y., Zhang, Y., Zhang, X. J., Wang, H., Du, Y., Guan, J., Wang, X., & Fu, J. (2021). NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway. Journal of Neuroinflammation, 18(1). https://doi.org/10.1186/s12974-021-02250-8
- Goody, M. F., & Henry, C. A. (2018). A need for NAD+ in muscle development, homeostasis, and aging. Skeletal Muscle, 8(1). https://doi.org/10.1186/s13395-018-0154-1
Posted in: Health > Whole Body Wellness > Energy,
Dr. Edward Group, DC
FOUNDER | HEALER | ADVOCATEDr. Group, DC is a healer and alternative health advocate, and an industry leader and innovator in the field of natural health who is dedicated to helping others. He is a registered doctor of chiropractic (DC), a naturopathic practitioner (NP), and proud alum of Harvard Business School and MIT Sloan School of Management. Dr. Group, DC is the founder of Global Healing – a mission and vision he has shared through best-selling books and frequent media appearances. He aims to spread his message of positivity, hope, and wellness throughout the world.
